Number of publications over time

Number of publications worldwide

Reporting quality of publications

Below you can see the number of publications for each transgenic AD model (left) and the reporting quality by model type (right). Select a date range to filter by time. Risk of bias reporting e.g. randomisation to group, blinded outcome assessment, conflict of interest statements (COI) and sample size calculations (SSC) is shown for all model categories. Click on the large chunk of any category on the Sunburst chart below to see all the relevant models and click an individual model to see the reporting quality of publications for that specific model. To return to the original risk of bias plot, select all data by clicking the centre of the sunburst plot, labelled Tg.


Number of publications using each Tg Model

Reporting quality

Below you can see the number of publications for each intervention tested in transgenic AD models (left) and the reporting quality by outcome type (right). Select a date range to filter by time. Risk of bias reporting e.g. randomisation to group, blinded outcome assessment, conflict of interest statements (COI) and sample size calculations (SSC) is shown for all model categories. Click on the large chunk of any intervention category on the Sunburst chart below to see all the relevant interventions and click an individual drug to see the reporting quality of publications for that specific intervention To return to the original risk of bias plot, select all data by clicking the centre of the sunburst plot, labelled Interventions.


Number of publications using each intervention

Reporting quality

Below you can see the number of publications for each outcome tested in transgenic AD models (left) and the reporting quality by outcome type (right). Select a date range to filter by time. Risk of bias reporting e.g. randomisation to group, blinded outcome assessment, conflict of interest statements (COI) and sample size calculations (SSC) is shown for all outcome categories. Click on the large chunk of any outcome category on the Sunburst chart below to see all the relevant outcomes and click an individual outcome to see the reporting quality of publications for that specific outcome To return to the original risk of bias plot, select all data by clicking the centre of the sunburst plot, labelled Outcomes.


Number of publications using each outcome

Reporting quality

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Alzheimer's disease data from publications have been generated according to a protocol available here.

Risk of bias regular expression dictionaries have been adapted from original dictionaries built by Dr Zsanett Bahor. Earlier versions of these have been used previously to assess reporting quality. Regex dictionaries for transgenic model, drug, and outcome measures are custom built for this project.

Text-mining was performed in R uisng the AutoAnnotation package created by Dr Jing Liao

If you have any questions about this dataset please contact kaitlyn.hair@ed.ac.uk

If you would like to use it for your review, please cite: Hair, K. (2020, February 11). Living Evidence: Transgenic Animal Models of Alzheimer's Disease. Retrieved from https://camarades.shinyapps.io/LivingEvidence_AD/